expression profile of circulating exosomal microrna in patients with oral potentially malignant disorders

Abstract

Oral Potentially Malignant Disorders are any oral mucosal conditions that are newlinestatistically associated with increased risk of developing oral cancer. The global newlineprevalence of OPMDs is reported to be between 1 and 5% and a high newlineprevalence of OPMDs is reported from South and East Asia with male newlinepreponderance, and malignant transformation rates of over 2% per year. newlineExosomes are extracellular vesicles containing genetic and protein components newlinereleased from normal and malignant cells. Exosomes are present in a variety of newlinebody fluids like blood, saliva, urine etc. Exosomes are found rich in liquid biopsy newlinewith concentrations of and#8805;10 newline9 vesicles/mL. miRNAs are small noncoding RNAs newlinefound in exosomes made up of 18 25 nucleotides in length with a crucial role in newlineposttranscriptional regulation of gene expression. Numerous clinical studies newlinehave demonstrated that the malignant potential of OPMDs was related to the newlinedysregulation of microRNAs. newline