an evaluation and design of knowledge discovery techniques for talent forecasting in human resource applicationInvestigation On Strategies to Improve Oral Bioavailability of Selected Bcs Class Iv Molecule

Abstract

Eprosartan mesylate (EM) is an angiotensin receptor blocker that suffers from newlineextremely poor bioavailability owing to its poor solubility and poor permeability. The newlinework was directed at developing formulation strategies to enhance the aqueous newlinesolubility and thereby its oral bioavailability. This would enable a reduction in the dose newlinewhich would eventually lead to fewer side effects. This work was divided into two newlinestudies, the first involved the formulation of EM nanosuspension, and the second study newlineinvolved the preparation of an EM-loaded self-nanoemulsifying drug delivery system newline(SNEDDS). newlineOptimization and characterization of nanosuspension based delivery of newlineeprosartan mesylate newlineThe rationale of the present work was to design the drug delivery system capable of newlineovercoming the solubility and bioavailability constraints of EM by preparing a newlinenanoemulsion. Quality by design principles was implemented to understand the product newlineand process variables of the sonoprecipitation technique, for the preparation of EM newlinenanosuspension. A quality risk management approach was utilized to identify and newlineassess high-risk attributes affecting critical quality attributes (CQA s), prioritizing the newlinenumber of experiments. The effect of the critical material attribute (CMA s) and critical newlineprocess parameter (CPP s) (ultrasonication amplitude, Soluplus® concentration, and newlinedrug concentration) on z-average particle size and PDI were investigated using central newlinecomposite face-centered design (CCF). Further, a design space with criteria set of newlineCMA s and CPP s was established to assure quality. The optimal formulation, newlineidentified using the numerical optimization method, was further lyophilized and newlineevaluated for redispersibility, saturation solubility, and in vitro dissolution behavior. newlineThe EM nanoparticles were amorphous as confirmed by differential scanning newlinecalorimetry (DSC) and X-ray diffraction (XRD) studies.