Identification screening and exploring potentials of pkc directed molecules in anti cancer drug development

Abstract

Protein Kinase C PKC is an important serine threonine kinase regulating crucial signalling pathways in mammalian cell biology During the PhD work the role of Protein Kinase C PKC in driving tumorgenicity and the potential of PKC in the development of anticancer drugs have been explored To fulfill these objectives we have designed novel chemical molecules selected the heterocyclic compounds from different chemical libraries Drug databank and phytochemical reservoir Our results indicate