The Study of Immunomodulatory activity of Purified Isolated Bioactive Compound from Moringa oleifera Moringaceae

Abstract

The aim of the present study was to investigate the immunomodulatory action of methanolic extract of Moringa oleifera in an experimental model of immunity. The cellular immunity was evaluated using neutrophil adhesion test, cyclophosphamide induced neutropenia and carbon clearance assay, whereas, humoral immunity was tested by mice lethality test, serum immunoglobulin estimation and indirect haemagglutination assay in animals Searching of substances with immunostimulative or immunorestorative effects could contribute to the maintenance of the immune system. Immune modulation helps in maintain disease free State of body. Many plants have been evaluated for immunostimulant and immunosuppressive properties using simple techniques. An attempt has been made to evaluate the immunomodulatory activity of the isolated bioactive compounds that showed potent antioxidant activity using different by investigating its effect on both humoral as well as cell mediated immunity using different models as: Haemagglutination antibody titre, cyclophosphamide induced myelosupression, Delayed type hypersentivity and phagocytic index. The immunomodulatory property of the oleanolic acid and isoquercitrin using different animal models was evaluated, which showed that these phytoconstituents augment humoral immune response, suppress cellular immune response and activate macrophage-induced phagocytosis. newline