Synthesis of a novel Heterocyclic Compounds and Nitration of Aryl Heteroaryi compounds

Abstract

Our aim of the study is to find out the novel synthetic methodology towards bioactive newlineheterocyclic moieties and industrially important compounds, by means of one-step or one-pot newlinemulticomponent synthesis and to design a facile approach with simple and environmentally newlinebenign method by considering environmental hazardous associated with organic solvent newlineusing novel catalytic methods to improve the yield with short reaction time. Therefore, we newlinefocused on usage of catalyst such as heteropolysolid acid catalyst, nanoparticles and newlinenanocomposite material instead of traditional catalysts. Moreover, the use of these catalysts newlineunder solvent-free reaction is becoming very popular as it has many benefits, like faster rate newlineINTRODUCTION newlinePage 14 newlineof reaction, clean product profile, recyclability, cost effective, more efficiency and remarkable ability to minimize side reactions in acid sensitive substrates. newlineThe objectives of the thesis are outlined below. newlineand#61692; To design and synthesis of triazole-urea analogues as fatty acid synthase-thioesterase (FASN-TE) inhibitors for anticancer drug. newlineand#61692; Synthesis of biologically active substituted benzoxazoles using phosphotungestic acid (PTA) and TiO2-ZrO2 composite as an efficient catalyst under solvent and solvent free condition. newlineand#61692; Development of efficient methodology for synthesis of and#945;-aminophosphonates using Cu (II)-and#946;-cyclodextrine as a nanocatalyst through one-pot multicomponent reaction under solvent free condition. newlineand#61692; Efficient methodology for the preparation of biologically important organic moieties such as 2-napthol Mannich base (Betti base) using zeolite as catalyst. newlineand#61692; Efficient methodology for the nitration of aromatic phenolic compounds using silica supported aluminium nitrate as nitrating agents. newline