Synthesis Characterization and Application of Functionalized Graphene Quantum Dots Incorporated Micro Nano Poly N N Diethyl Acrylamide Hydrogel as Drug Delivery System

Abstract

Cancer has emanated as a daunting menace to human-kind even though medicine, newlinescience, and technology has reached its zenith. Subsequent scarcity in the revelation of newlinenew drugs, the exigency of salvaging formerly discovered toxic drugs such as newlinedoxorubicin has emerged. The invention of the drug carrier has made drug delivery newlineimminent which is ascribable to its characteristic traits of specific targeting, effective newlineresponse to stimuli and biocompatibility. Temperature responsive polymers hold great newlinepromise in biological applications as they respond to change in environmental newlinetemperature to produce the desired effect like controlled drug delivery. The objective newlineof this work is to develop macro and nano forms of temperature responsive hydrogels newlineintended for drug delivery applications. This work deals with the synthesis and newlineoptimization of macroporous temperature responsive hydrogel poly (N, N-diethyl newlineacrylamide) (PDEA) was via free-radical-polymerization. The optimized hydrogel was newlineachieved by evaluating the swelling characteristics, physical stability, and mechanical newlinestrength; through altering the components namely concentration of N, N-diethyl newlineacrylamide (monomer), ammonium peroxodisulfate (initiator), N, N -methyl newlinebisacrylamide (cross-linker) and N, N, N , N -tetramethyl ethylenediamine newline(accelerator). LCST of the polymeric carrier has been modified by the addition of newlinegraphene quantum dots (GQDs). Inverse emulsion polymerization method was used to newlinesynthesize PDEA and GQDs incorporated PDEA nanohydrogels. Operating parameters newlinelike stirrer speed, water/oil ratio, and surfactant concentration were varied to optimize newlinethe conditions for the production of nanohydrogels. newlineFrom the temperature responsive studies, it has been observed that the equilibrium newlineswelling ratio (ESR) and reswelling kinetics of the hydrogel significantly increased as newlinethe GQDs content was varied.