Next Generation Sequencing Molecular Profiling of Myeloid Neoplasm

Abstract

newlineMyeloid malignancies including acute myeloid leukemia myelodysplastic neoplasms and myeloproliferative neoplasms are heterogeneous disorders with diverse cytogenetic and molecular alterations The incorporation of molecular genetics into diagnostics has transformed patient care particularly with next generation sequencing which enables simultaneous analysis of multiple clinically relevant genes Recent NCCN WHO ICC and ELN newlineguidelines recommend molecular workup for risk stratification and personalized treatment especially with the advent of targeted therapies Such approaches allow newlineidentification of diagnostic markers provide prognostic insights and guide therapeutic decision making in hematological malignancies newline newline