Design Synthesis and Evaluation of Anticancer Activity of Some Novel Heterocyclic Compounds

Abstract

Plethora of chemotherapeutic drugs are available for cancer treatment. It is self-evident that due to decreased body immunity, cancer patients on chemotherapy are more vulnerable to bacterial infections. Therefore, additionally along with the chemotherapeutic drugs, other drugs have also been co-administered to treat or prevent microbial infections. To resolve this, the development of single drug monotherapy with dual function is the demand of the hour. newlineBased on designed SAR with literature survey and chemistry, substitutions were attached to 3rd and 5th position of thiophene to prepare a two series of thiophene linked 1,3,4-Oxadiazole and 1,2,4-Triazole derivatives. The designed molecules were synthesized using conventional method and structurally characterized by spectroscopic techniques. All synthesized compounds were screened for in-vitro anticancer activity by 3-[4, 5-dimethylthiazole-2-yl]-2, 5- diphenyltetrazolium bromide (MTT) assay. It was found that compound 4a,4d, 4e,4j, 4l, 4m, 6a, 6c, 6d, 6e ,6g and 6m exhibited good antiproliferative profile. In silico ADME studies also revealed that the synthesized compounds have the potential to act like drug molecule. Further molecular docking study was performed to screen their binding pattern with the biological targets, and it was confirmed that 4d, 4e, 6d, 6e and 6g based on their binding pattern against EGFR and aromatase can be considered as good anticancer agents. newline