Studies on the Synthesis Characterisation and Biological Evaluation of Pyrazoles and Pyrazolo Pyramidine Derivatives

Abstract

Heterocyclic compounds are widely distributed in nature and have very significance role in newlinelife. They play a vital role in the metabolism of all living cells. Nitrogen containing heterocyclic newlinecompounds are placed at the topmost in the field of pharmaceuticals and agrochemical newlineindustries. The biological importance of Nitrogen containing heterocyclic compounds have made newlinethem scope for synthesis. newlineThe synthesis of nitrogen heterocyclic compounds and their derivatives occupy a centre newlinestage in the realm of natural and synthetic organic chemistry due to their biological newlineand medicinal properties. They are considered as an important class of compounds over several newlinethousand existing drugs. Apart from the biological uses , Nitrogen heterocyclic compounds are newlineideal chemical molecules for making libraries of drug intermediates and to generate newlinelibraries of inhibitors of HIV-1 protease. About 99.00% of Nitrogen based organic compounds newlineexhibit excellent biological significance than non-nitrogen based organic compounds newline1-9 newline. After reviewing literature, we showed interest on the synthesis of some nitrogen based newlineheterocyclic compounds like, pyrazole, pyridine, pyrimidine and fused pyrimidine derivatives. newlineAlthough a number of modified methods under improved conditions reported for the newlinediscovery of these classes of compounds, most of the methods are generally carried out in newlineorganic solvents, involving longer reaction time, high temperature and expensive catalysts. Moreover disadvantages in most of the existing methods are the catalyst is destroyed in the newlinework-up and cannot be recovered or reused. Due to the immense biological importance of nitrogen newlinecontaining heterocyclic compounds, we grabbed attention towards the synthesis of some newlinenitrogen heterocycles and evaluate their biological activity newline10-19 newline newline