Microemulsion based transnasal delivery system for brain

Abstract

The project was undertaken with an aim to develop oil in water microemulsion based intranasal newlinedelivery system for brain targeting for treatment of epilepsy. Carbamazepine and Phenytoin, newlinewidely used antiepileptic drugs, were selected for this study. These drugs are currently available newlinein the form of oral and injectable dosage forms. Oral therapy results in slower brain uptake and newlinesystemic side effects while injectable therapy requires need of trained person which may not be newlineavailable at the time of seizures. Hence novel patient friendly intranasal formulation was newlineproposed to provide faster on set of action during seizures.