Design and Efficient Synthesis of Various Novel Pyran Nitriles Triazole_Quinazoline Hybrids and Benzazole Phthalimide Derivatives

Abstract

The thesis entitled Design and efficient synthesis of various novel pyran nitriles, triazole- quinazoline hybrids and benzazole phthalimide derivatives has been divided into five chapters. newline newline newlineCHAPTER-1 newline newlineThis chapter describes a general introduction, mechanism of action and pharmacological aspects of Phthalazines, Quinazoline, Benzimidazole and Benzothiazole derivatives. It also covers the preface about the Phthalazines, Quinazoline, Benzimidazole and Benzothiazole derivatives and their medicinal importance in detail. newline newline newlineCHAPTER-2 newline newlineIn this chapter, all the attempted methods to synthesize the 2-amino-6-(1,4-dioxo-3,4- dihydrophthalazin-2(1H)-yl)-4-phenyl-4H-pyran-3,5-dicarbonitriles were explained in detail. Successfully developed a simple one pot for synthesis of novel 2-amino-6-(1,4-dioxo-3,4- dihydrophthalazin-2(1H)-yl)-4-phenyl-4H-pyran-3,5-dicarbonitrile with simple work up procedures in green methods. All the synthesized compounds were characterized by IR, 1H NMR, 13C NMR and Mass spectral data. newlineCHAPTER-3 newline newlineIn this chapter, a variety of 1,2,4-triazolo[4,3-c]quinazoline derivatives were synthesized in an efficient manner and the compounds were well characterized by spectroscopic methods. The newline newlinesynthesized compounds were tested for possible anticancer activity against two cancer cell lines and some of the compounds displayed substantial activity and also studied the binding interactions by docking scores. newline newline newlineCHAPTER-4 newline newlineIn this chapter, Green synthetic methods have been developed for the synthesis of benzazole phthalimides in PEG-600 through step wise fashion and tandem reaction with good yields. In additional, the synthesized compounds were subjected for molecular docking and the results revealed that the molecules exhibited good binding affinity towards tubulin protein which indicates their anti-mitotic nature. All the synthesized compounds were characterized by IR, 1H NMR, 13C NMR and Mass spectroscopy. newline newlineCHAPTER-5 newlineThis chapter presents the conclusions of the current research work.