Studies on Kinetics and Mechanism of Pharmaceutical Drugs with Suitable Oxidizing Agent

Abstract

The present thesis entitled Studies on Kinetics and mechanism of Pharmaceutical drugs newlinewith suitable Oxidizing agent encompasses seven chapters, each of which has discussed newlinethe results with proper justification and evidences backed up by appropriate mathematical newlineand kinetic validation. newlineChapter 4.1: Kinetic and Mechanistic Studied on Oxidation of 1, 3- newlineDiphenyl Thiourea by Cetyltrimethyl ammonium Permanganate in newlineSolvent Free State newlineThe Kinetics of oxidation of 1,3-diphenyl thiourea by Cetyltrimethyl ammonium newlinepermanganate was studied in solvent free condition. Thiourea derivatives are important newlinechemical building blocks that have numerous pharmaceutical and chemical applications. newlineThey are used as efficient guanylating agents, in primary or secondary vulcanization newlineprocess as accelerator, in photographic film, elastomers, plastics, textiles, metal refining newlineas corrosion inhibitor and in metal cleaning process. The reaction shows first order newlinedependence in cetyltrimethyl ammonium permanganate and 1,3-diphenyl thiourea which newlinesupports the derived rate law. Increase in ionic strength using Potassium nitrate has no newlinesignificant effect on reaction rate. The stoichiometry of the reaction was found to be 2:3 newlineand the oxidation products were identified as 1,3-diphenyl urea which gives molecular ion newlinepeak at 213.2 MHz in LCMS. The effect of temperature on the rate of reaction has also newlinebeen studied and the activation parameters have been evaluated and values are found to newlinebe Ea=57.03 kJ/mol, and#8710;H# newline=54.32 kJ/mol, and#8710;S# newline=-123.92 J/K/mol, and#8710;G# newline=90.84 KJ/K/mol and newlinelog10A=2.0. Rate law is derived as 1 / kobs = 1 / k1 k2 [DPTU] + 1 / k2. The reaction newlineconstants involved in the mechanism were computed. A probable mechanism has been newlinesuggested on the basis of experimental observations. newlineChapter 4.2: Comparative Kinetic and Mechanistic approach of newlineOxidation of Pyrmetazole by Permanganate (VII) and Ferrate (VI) in newlinealkaline medium newlinePyrmetazole is an intermediate used in the production of gastric proton pump inhibitors newlineomeprazole and es