In Vitro and in Vivo Evaluation of Wound Healing Potency of Adathoda Vasica

Abstract

Type 2 diabetes is a metabolic disorder characterized by improper glucose homeostasis due to resistance to insulin. Persistent diabetes can lead to the risk of lower limb amputation. 25% of the total diabetic population develop diabetic foot ulcer and 84% of the DFU patients encounter lower leg amputations during their life time. In vivo diabetic models can be genetically derived or induced by nutrition/diet feeding have enormous contributions to research of diabetic wound healing and its related complication. Although there is milestone achieved in the discovery of anti-hyperglycemic drugs, there is a need of replacement for these in existence due to their limitations or side effects. The current study has evaluated the wound healing effect of Methanolic extract of A.vasica (AVME) on RAW 264.7, L926 Fibroblast, and HUVECs and in insulin resistant in vivo model newline