Evaluation of Influence of Herbal anti diabetic formulation on allopathic anti diabetic drugs

Abstract

quotABSTRACT newline newlineEvaluation of Influence of Herbal Anti-Diabetic Formulation on Allopathic Anti-Diabetic Drugs newline newlineThe present study was undertaken to assess the possible interactions of poly-herbal (Mehagni) which is an anti-diabetic formulation with GLB and GLM which are commonly used oral allopathic anti-diabetic drugs in T2DM. Total of 134 patients were divided into three groups. Group A (51 patients) with the GLB therapy (2.5 mg tablet/day, after food), Group B (38 patients) received the poly-herbal formulation (mehagni-500mg, 2 tablets thrice a day, after food) and Group C (64 patients) with the GLM therapy (2 mg tablet/day, after food) from the last six months. Baseline anthropometrics and clinical characteristics were assessed in all patients. The specific instructions regarding diet and amendments in life style were provided by the study co-ordinator to patients. newline newlineAt the end of the 12th week, in combination therapy the significant reduction in fasting blood sugar. The levels of high density lipoprotein (HDL) were significantly increased. Furthermore, the pharmacokinetic study (PK), the Cmax of allopathic drugs increased significantly in combination therapy as compared to individual treatments and no patient has experienced hypoglycemia. newline newlineBased on these results, we conclude that administration of poly-herbal formulation in combination with allopathic anti-diabetic formulations GLB and GLM has significant effect in reducing the dose of allopathic anti-diabetic formulations to achieve better therapeutic response with minimal side effects. The co-administration of poly-herbal formulation with allopathic anti-diabetic drugs exhibited better glycemic control along with lipid lowering effect. newline newlineKEYWORDS: Diabetes; Blood glucose; Lipid profile; Pharmacokinetics; Poly-herbal formulation; Mehagni; Glibenclamide; Glimepiride; Type 2 diabetic patients. newline