Studies in synthetic elaboration at and#913; C H centres of amines

Abstract

The objective of this thesis to explored the lithiation/substitution reactions of in situ generated and#945;-hetero carbanions with various electrophiles. This work is divided into two chapters. Chapter1 is about the development of new protecting group/s and study the protection deprotection of secondary amines using the developed protecting group. It was of interest to see if it was of use in the regioselective deprotonation of the secondary amines. For this purpose 1,2,3,4-tetrahydroisoquinoline was chosen as the model compound. In this chapter, we have described the successful syntheses of various N- protected THIQs and the lithiation substitution reactions of N-protected THIQs with various electrophiles. Chapter2 describes the attempted synthesis of 6,12-substituted Troeger base via nucleophilic addition of and#945;-amino carbanions, derived from Troeger Base, to in situ generated arynes as well as with electrophiles. newline