Impact of Non Alcoholic Fatty Liver Disease with Diabetes Mellitus Type II

Abstract

ABSTRACT newlineIntroduction: Nonalcoholic fatty liver disease (NAFLD) is an alarming public health newlineproblem. The disease is one of the main causes of chronic liver disease worldwide and newlineis directly linked to the increased prevalence of obesity and type 2 diabetes mellitus newline(T2DM) in the general population. Non-alcoholic fatty liver disease (NAFLD) and newlinetype 2 diabetes (T2DM) are common conditions that regularly co-exist and can act newlinesynergistically to drive adverse outcomes. newlineNon-alcoholic fatty liver disease (NAFLD) is the most prevalent liver condition newlineworldwide. NAFLD has been associated with metabolic syndrome and its symptoms, newlinesuch as type 2 diabetes, hypertension, dyslipidemia, and obesity. Ultrasound is widely newlineused to grade hepatic steatosis, being the most cost-effective, non-invasive, and newlinereadily available modality without radiation exposure. newlineNoninvasive assessment and staging of disease are based on clinical parameters such newlineas age, sex, liver function test, platelet count, lipid profile, BMI, and imaging newlinemodalities such as USG, transient elastography (TE), and magnetic resonance newlineimaging mass spectroscopy. Such clinical scoring systems and TE are useful in the newlineearly detection of NAFLD and predicting fibrosis. newlineThe mainstay of NAFLD management is currently to reduce modifiable metabolic newlinerisk. Achieving good glycemic control and optimizing weight loss are pivotal to newlinerestricting disease progression. Once cirrhosis has developed, it is necessary to screen newlinefor complications and minimize the risk of hepatic decompensation. The principle newlinebehind the management of NAFLD with T2DM involves an indirect effect through newlineimprovement in IR and glycemia and thus is used for the treatment of T2DM as well. newlineTherefore, the objectives of the present study were: newline1. To study the prevalence of NAFLD in patients with type 2 diabetes mellitus newlinepatients. newline2. To study the risk factors like age duration of diabetes mellitus type II, BMI, newlineWHR, hypertension, liver Enzymes, fasting and post-prandial sugar levels, HbA1c newlineand