A Comparative Study Of Neutrophil To Lymphocyte Ratio Monocyte To Lymphocyte Ratio Platelet To Lymphocyte Ratio In Type 2 Diabetes Mellitus Patients With And Without Complications

Abstract

Diabetes mellitus is a frequent chronic disease with high newlinemorbidity and mortality. 1 Diabetes is a major public health concerns newlineworldwide, especially type 2 DM. 2 The world health organization newline(WHO) estimated the increase in type 2 DM approximately 46%, newlinefrom 55 million in 2000 to 83 million in 2030 in developed nation; newlinewhereas, developing nation may increase approximately from 30 newlinemillion in 2000 to 80 million in 20 30, accounting for 150% newlineincrease. 2 newlineIndia being top in the chart with estimated tendency to newlineincrease from 31.7 million in 2000 to 79.4 million out of 366 newlinemillion worldwide by 2030, making India in the process of making newlinediabetic capital of the world. 1 ,2 One of the common complications newlineof diabetic mellitus on eye is diabetic retinopathy. Its manifestation newlineis linked to the duration of diabetes, as proved by Wisconsin newlineepidemiological study. Several studies have reported an incre ase in the levels of newlineinflammatory cytokines such as c -reactive protein (CRP), newlineinterleukin (IL)-1, IL-6 and tumour necrosis factor (TNF)-a in newlinepatients with diabetes. 8 ,9 Inflammatory cytokines are produced by newlinedifferent cell types, released into circulation a nd have local, central newlineand peripheral effects on different tissue types. 1 0 Two of the main newlineconditions of prediabetes are impaired levels of fasting glucose newline(IFG) and impaired glucose tolerance (IGT). IFG is defined as the newlinefasting plasma glucose level ranging from 100 mg/dL (5.6 mmol/L) newlineto 125 mg/dL (6.9 mmol/L). IGT is a condition characterized by a 2 - newlineh plasma glucose value in the oral glucose tolerance test, ranging newlinefrom 140 mg/dL (7.8 mmol/L) to 199 mg/dL (11.0 mmol/L). Another newlineprediabetic condition is gl ycated haemo-globin (HbA1C) that ranges newlinefrom 5.7% to 6.4%. 1 1 Macrovascular complications are twice as newlinecommon in people with IGT as in normoglycemic individuals. newlineThis study investigated and compared the NLR, PLR, MLR newlineand certain biochemical levels of participants with normal glucose newlinetolerance (NGT), IGT, newly diagnosed diabetes