The Molecular Mechanism behind Nephroprotective Role of Pueraria tuberosa Roxb ex Willd DC

Abstract

There is a rising incidence of renal failure, with poor outcomes and high cost throughout the world. Chronic kidney disease, also called chronic kidney failure is defined as the presence of kidney damage, manifested by abnormal albumin excretion or decreased kidney function, quantified by measured or estimated glomerular filtration rate (GFR) over a time, usually months to years. Major clinical factors for the susceptibility of chronic kidney diseases includes diabetes, hypertension, glomerulonephritis, autoimmune disease, polycystic kidney disease, urinary tract infection, systemic infection, neoplasia, family history of chronic kidney diseases, reduction in kidney mass, and exposure to certain drugs etc. Diabetes is a metabolic syndrome and its prevalence is increasing globally as a result of urbanization, human aging and change in lifestyles newline