Formulation and biopharmaceutical Evaluation of nebivolol hcl stealth Nanostructures using quality by design

Abstract

newline Abstract newlineIn the last few decades, lipids have gained importance in delivering poorly newlineaqueous soluble drugs. The availability of various lipids that are enclosed in generally newlinerecommended as safe (GRAS) with their ability to enhance oral bioavailability has newlinehelped in the development of lipid-based formulations as a means for drug delivery. newlineAfter the discovery of solid lipid nanoparticles by Professor R. H. Muller (Germany) newlineand Professor M. Gasco (Itlay) in early 90s, created a new ray of hope in developing newlinestable lipid formulations with increased drug efficacy. During the past decade, the newlineminute disadvantages observed in SLNs have made the researchers to discover newlinenanostructured lipid carriers and number of studies were increased drastically due to newlinetheir effective drug delivery in predetermined time points. newline