Neuropharmacological Profile of Indian Medicinal Plant

Abstract

Medicinal herbs are indispensible part of traditional medicine practiced all over the world due to easy access, low cost, least risk and low side effect profile. Anacyclus pyrethrum, Family Asteraceae is used in traditional system of medicine and it is regarded as a tonic to the nervous system. The plant roots are reported for antibacterial, anti-inflammatory, immunostimulating and aphrodisiac activities. As root of this plant has potential health benefits, it can be better utilized for nutraceutical and functional food formulations. The present work was undertaken to study neuropharmacological role of Anacyclus pyrethrum in consideration to memory improvement activity to treat the diseases related to cognition and use in learning and memory processes. In phytochemical analysis ethanolic extract of roots of Anacyclus pyrethrum showed more number of phytoconstituents. Ethanolic extract of Anacyclus pyrethrum was found have significant inhibition on acetylcholinesterase activity by spectrophotometric and TLC plate bioassay detection for AChE inhibition. TLC and HPTLC of ethanolic extract of Anacyclus pyrethrum were done. The good resolution of spots in TLC and HPTLC shows the presence of various active principles in the extract. Total phenolic, flavanoid, ascorbic content in ethanolic extract of Anacyclus pyrethrum was quantified. Exvivo methods such as lipid peroxidation assay also suggest antioxidant potential of the extract. In conclusion, the present study revealed ethanolic extract of Anacyclus pyrethrum have memory enhancing property, antidepressant activity and neuroprotective role which may be due to its anticholinesterase potential, effect on neurotransmitters such as dopamine and serotonin level and its antioxidant profile, therefore it seem that Anacyclus pyrethrum may prove to be useful in treatment of dementia of Alzhemier diseases. Further studies are to be warranted for its safety, efficacy and mechanism of action for its therapeutic potential. newline newline newline