Nutrient Dependent Regulation Of The Transcriptomic Dyn In Hematopoietic Progenitors Of Drosophila And Human

Abstract

newline In the intricate landscape of hematopoietic progenitor development, a complex framework of newlineregulatory mechanisms orchestrates the dynamic changes in gene expression profiles. My newlinethesis embarks on an investigation towards the identification novel mechanistic underpinnings newlineimposed onto the intrinsic regulatory elements like micro RNAs and extrinsic newlinemicroenvironmental cues that fine tune the expression of transcriptomic landscapes of newlinedevelopmentally relevant cell type The Hematopoitic Progenitors . newlineCentral to this exploration is the unveiling of the autophagy of microRNAs (miRNAs) that newlinecontribute to the fine tuning of a cell s transcriptomic landscape. MiRNAs are small RNA newlinemolecules that play a crucial role in regulating gene expression 1 . They are involved in various newlinebiological processes, including development, differentiation, and disease progression 2 . newlineUnderstanding the turnover of miRNAs is essential for unraveling their regulatory mechanisms newlineand their impact on cellular processes and disease biology. While the biogenesis and newlinemechanisms of action of miRNAs have been extensively studied, the turnover of miRNAs and newlineits relationship with mRNA autophagy is an aspect that is yet to be fully deciphered. newlineResearch on miRNA turnover has raised questions about the stability of miRNAs. Some studies newlinesuggest that miRNAs are typically stable, while others propose that they are subject to active newlineregulation newline3,4 newline. The turnover of miRNAs is a dynamic process that involves their degradation newlineand clearance from the cell which in turn can impact their abundance and, consequently, their newlineregulatory activity 5 . The thesis illuminates the intricate interplay of miRNAs undergoing newlineautophagic degradation, thus unveiling a previously uncharted aspect of regulation in newlinehematopoietic progenitor gene expression. This discovery underscores the intricate nature of newlinecellular control mechanisms during the process hematopoietic amplification in the progenitor newlinestate. newlineWith an account toward evolution, the thesis conducts a comparati