Supplementary Role of Curcuma longa and Zingiber 0fficinale Alongwith Metformin for Treatment of Polycystic Ovarian Syndrome In Female Mice Mus musculus

Abstract

One of the most common causes of female infertility is polycystic ovarian syndrome, which affects 6 21% of the population. Regrettably, the currently available treatments are mostly symptomatic and ineffective. As a result, safer options are needed now more than ever. In a letrozole PCOS albino mouse model, the current study compares the therapeutic advantages of turmeric extract and ginger extract to metformin. The effects of Turmeric Extract and Ginger extract in contrast to Metformin in endocrine- metabolic abnormalities in experimentally induced PCOS mice model, were studied in this study. Letrozole (6 mg/kg) was administered orally (p.o) for 21 days to induce PCOS, followed by a dose of Turmeric Extract (Curcuma longa) (175 mg/kg and p.o), Metformin (150 mg/kg) and ginger (350mg/kg) for 30 and 60 days, both with normal saline water (0.9%) as the carrier. The findings revealed that LET-treated mice displayed PCOS-like characteristics, such as higher LH levels, increased body weight, and ovarian morphology with numerous cysts, increase in fasting blood glucose, lipid profile, , as well as a decrease in serum Progesterone, Estrogen and FSH levels. These changes were reversed when treated turmeric and ginger extract. newline