The study of 1 2 3 triazol 4 heptylpiperazin thiosemicarbazone and thiodiazole derivatives binding interaction mechanism in protein dna molecule

Abstract

Malignancy is the most feared diseases on the planet. The main problem about this kind of disease is due to the lacking of understanding the biochemical mechanism. Cancer in India is also considered as a second most common disease which have made havoc impact/ or big threat in the rate of mortality of about 0.3 million per year with a gradual increase in the number of cancer patients every year. All types of cancers have been reported in Indian population of which most frequently observed were lungs, breast, colon, rectum, stomach and liver. World Health Organization has reported about the current rate of mortality due to cancer in India, which indicates that it was considerably lower than those occurred in the developed countries including USA. Among various treatment modalities of cancer, the following methods are most widely considerd: (1) Surgery :- Consist of removing the tumor in part; (2) Radiotherapy :- Exposing the tumor to ionizing radiation viz X ray and gamma rays and particles which prevents the diseased cells from multiplying and destroys them; (3) Chemotherapy :- Comprise of regulating systemic therapeutic substances to obliterate the dangerous cells or keep them from spreading. Among these, chemotherapy is mainly preferred for advanced stages of cancer. Based on the interaction of chemotherapeutic agents, they are classified as cytostatic and cytotoxic agents. The former is used to stabilise the cell by preventing the proliferation of the cells while the later is killing of cancer cells through necrosis and apoptosis mechanism. Chemo preventive drugs interfere with the replication of the DNA by a group of molecules such as antimetabolite, alkylating and DNA binding agents. The newlineantimetabolites are molecules that mimic nucleotides and are incorporated in DNA/protein resulting in the non functionality of DNA/protein. Whereas alkylating agents are molecules which attach permanently to the DNA/protein thereby distorting its shape and disengage from the chain. newline newline