Anti Arthritic Potential of Standardized Extract of Clerodendrum Serratum L A Traditional Medicinal Plant

Abstract

Arthritis is a chronic inflammatory disease with restricted joint movement. The pathophysiology of arthritis is not clearly illustrated. An external factor like (e.g., smoking, infection, or trauma) that give rise to an autoimmune reaction, enduring inflammation of joints associated with hidden extra-articular manifestations. The synergy of genetic and environmental factors raises various types of complex immune response, which finally damages joint and bone. Epidemiologic data indicate that globally about 1% of people suffer from arthritis. newlineManagement strategy includes nonsteroidal anti-inflammatory drugs (NSAIDs), use of disease-modifying anti-rheumatic drugs (DMARDs) and corticosteroids (steroids). Above mention existing synthetic drugs have several drawbacks due to extra-articular manifestations or co-morbidities. Major side effect includes gastrointestinal bleeding; cardiovascular problems associated with chronic arthritis conditions. newlineNatural products play an important role for new pharmaceuticals and chemical entities. WHO guidelines also rigorously commend the standardization of medicinal plants for their safety and efficacy. With this background, current work is invented to standardize the Clerodendrum serratum extract and evaluate biological activity as anti-arthritic and for scientific validation of traditional claim as an anti-arthritic agent. The objective was to assess the richness of ethno-medicinal plant species with an appropriate scientific approach, practiced by the different communities for arthritis disorders. newlineRoots of Clerodendrum serratum L. (Verbenaceae) was procured from the local market of Faizabad, Uttar Pradesh, India. The taxonomical recognition was done from Department of Agronomy, Aacharya Narendra Dev Agriculture Technical University, Dist. Faizabad, Uttar Pradesh. newlineThe collected brown colored roots (100gm) were subjected to extraction (decoction) with water (500ml) maintaining temperature around 110°C for 2hrs.