An automatic insulin infusion system based on adaptive control algorithims

Abstract

newline v newlineAbstract newlineThe issue of continuous and controlled drug delivery is important for the treatment newlineof pain of various organs, diabetes and many other chronic medical conditions requiring newlinemedication for a long period. Most drugs, whether taken orally or via injection are newlinedelivered to the body system wide. The medication circulates throughout the body, newlineaffecting organs and cells that are dysfunctional as well as those are healthy. Site-specific newlinedrug delivery allows for higher drug concentration at the site, where it is actually newlinenecessary. Ingested or injected drugs often exhibit blood concentrations that peak and newlinedecay in an uncontrolled fashion. A more effective approach is to release medication newlinedirectly into the blood stream at a programmed rate to achieve the optimum dose as a newlinefunction of time. The programmable implantable medication systems thus require newlinesophisticated controllers. Efforts are being made to improve the control algorithms, so that newlinegreater miniaturization of the device is possible. In the present work, research has been newlineconcentrated on the design and analysis of a robust controller for implantable drug newlinedelivery system, which will produce the optimal output at every possible physiological newlinecondition and disturbances. Concentration is made on the problem of establishing a normal newlineoperating state and optimum setting of the controller for the implantable drug delivery newlinesystems. newlineThe implantable pumps currently in clinical trials have been sufficiently addressed, newlinebut not totally overcome. A number of critical design and performance obstacles are still newlinethere. Accuracy has reached remarkable levels, but thereand#8223;s always room for improvement. newlineThe motivation of the present research work has been to investigate and solve some major newlineissues related to complex control problems of implantable drug delivery systems. Though newlinethere are several applications of implantable drug delivery systems, initially the treatment newlineof type-I diabetes, which is a very common chronic disease in mankind, has been newlineconsidered. The complications of diabetes are thought to arise from poor control of blood newlineglucose (BG) concentration caused by inadequate production or action of insulin hormone newlinein the human body. The problem of blood glucose (BG) level control has