Development and Optimization of a Surface Engineered Injectable Depofoam System for Treating Urinary Tract Infections A Quality By Design Coupled with Risk Assessment Approach for Prolonged Drug Release

Abstract

The aim of this research endeavor is to develop and optimize injectable surface newlineengineered Depofoam formulations loaded with Aminoglycosides-Antibiotics for the newlineeffective treatment of Urinary Tract Infections (UTIs). The primary objectives encompass a newlinecomprehensive exploration of various facets of formulation development, spanning risk newlineassessment, formulation design using Quality-by-Design (QbD) principles, surface newlineengineering for enhanced performance, in-vitro characterization, formulation optimization newlinethrough Design of Experiments (DoE), stability evaluation, and preclinical investigations to newlineassess efficacy in animal models. This study embarks on a rigorous scientific journey, newlinecommencing with an in-depth analysis of the research objectives. newlineThe overarching aim of this research is to address the pressing clinical need for newlineimproved therapeutic interventions in the management of UTIs, a prevalent and burdensome newlinehealthcare issue globally. By leveraging innovative formulation strategies, the research newlineendeavors to develop surface-engineered Depofoam formulations that offer prolonged drug newlinerelease and enhanced efficacy against UTIs, ultimately contributing to improved patient newlineoutcomes and reduced antibiotic resistance newline