Study of Gastro Retentive Drug Delivery System GRDDS to enhance the oral bioavailability of Risedronate Sodium Glipizide and Carvedilol Preparation In vitro and In vivo evaluation

Abstract

The purpose of this study is to develop optimize and characterize the selected drugs Risedronate Sodium Glipizide and Carvedilol with Gastro Retentive Drug Delivery System GRDDS using a natural synthetic and semi synthetic polymer as a gel forming swelling release retarding and floating agent to enhance the oral bioavailability Different dosage form Risedronate sodium floating tablet Glipizide mucoadhesive microspheres and Carvedilol floating in situ gel were prepared with varying concentration of semi synthetic synthetic and natural polymers Guar gum Mimosa pudica seed mucilage and Limonia acidissima gum using sodium bicarbonate as a floating agent The formulations were studied to FT IR and DSC revealed that there is no interaction between the drug and polymer In vitro studies of all the dosage form were performed and showed satisfactory controlled drug release for more than 12 h with excellent buoyancy floating lag time less than 1 min floating duration greater than 12 h Radiographic studies of all optimized dosage form were performed with New Zealand albino rabbits using barium sulfate as a contrast media and the images showed that the dosage form were retained successfully in rabbit stomach for more than 8 h The relative bioavailability of all optimized dosage form showed significant increase in AUC when compared to conventional products Accelerated stability studies showed better physical stability with all optimized dosage form. Based on the study report it was concluded gastro retentive drug delivery system would be a promising system to enhance the oral bioavailability newline