Effectiveness of vestibular stimulation on learning and memory in scopolamine induced dementia in Wistar rats

Abstract

Dementia is a unique condition that not only affects normal aging but newlinealso affects work and social interactions and eventually the personal newlinerelationships. Slow and progressive deterioration, difficulty in early diagnosis newlineand lack of immediate intervention, makes the initiation of timely measures to newlinetreat dementia. The currently approved drug strategies are only of newlinesymptomatic treatment approach with limited and temporary relief together newlinewith considerable side effects. Hence, it is essential and timely to develop a newlinenatural, inexpensive and effective therapy with minimal side effects. Even newlinethough the potential of vestibular stimulation in enhancing learning and newlinememory is reported by various studies, its beneficial effects in treating newlinedementia are not mechanistically explored. Hence large-scale studies are newlineessential to ensure the efficacy and curative effects of vestibular stimulation in newlinedementia. This present study was hence undertaken to provide authoritative newlinedatabase for beneficial effects of vestibular stimulation and to validate newlinevestibular stimulation as a therapy for enhancement of cognition and delay the newlinesymptoms of dementia.The aim of the present study was to assess the effectiveness of caloric newlinevestibular stimulation on learning and memory in scopolamine induced newlinedementia in Wistar rats.It was observed that both bilateral and unilateral vestibular newlinestimulation has a positive effect on all cognitive, motor and anxiety related newlineparameters. Through our study it had been proven that vestibular stimulation newlineas an effective intervention to reduce the structural and functional effects of newlinedementia on brain. Improvement in various neurotransmitter levels and newlinehistopathogical studies underlines this fact. Vestibular stimulation has also newlinealleviated anxiety and improved motor co-ordination thereby relieving more newlinesymptoms of dementia. newline