Regulation of utrophin a expression in c2c12 cells through variations in 5 utr

Abstract

Duchenne Muscular Dystrophy (DMD) is the most frequent genetic newlinedisorder that affects 1 in every 3500 males worldwide. The cause of the newlinedisease is mutation in X-linked dystrophin gene. In absence of functional newlinedystrophin the sarcolemmal integrity is lost resulting in muscle destruction newlinethat leads to death. Dystrophin is one of the components of dystrophin newlineassociated protein complex (DAPC) which linked the cytoskeleton with newlineextracellular matrix. Utrophin is an autosomal homologue of dystrophin newlinethat can compensate dystrophin deficiency. Expression of utrophin in newlineadult is restricted to neuromuscular and myotendinous junctions. A two newlinefold increase in expression of utrophin in mice model has been shown to newlinereduce dystrophic pathology. Therefore upregulation of utrophin has been newlineconsidered as a potential strategy for DMD therapy. newline