Exploring the Antioxidant and Neuroprotective Properties of Synthesized Benzo BThiophene Analogues on Acrylamide Induced Oxidative Stress in Zebrafish Model

Abstract

Acrylamide is recognized not only for its widespread occurrence but also for newlineits neurotoxic effects, which pose serious health risks to the global population. Chronic newlineexposure to acrylamide can lead to oxidative stress-mediated neuronal damage, newlinecharacterized by the deterioration of neuronal structures and impaired motor functions. newlineGiven its potential to cause long-term neurological disorders, there is a critical need to newlineidentify effective agents that can counteract its harmful effects. This research focuses on newlinethe neuroprotective potential of novel benzo[b]thiophene analogues, specifically 1-(3 newlinehydroxybenzo[b]thiophen-2-yl) ethanone (BP) and 1-(3-hydroxybenzo[b]thiophen-2 newlineyl) propan-1-one hydrate (EP), which have shown promising antioxidant activities in newlinepreliminary studies. newlineThe foundational hypothesis of this thesis posits that oxidative stress is newlinepivotal in acrylamide neurotoxicity and that phenol-like hydroxyl groups, known for their newlinestrong free radical scavenging properties, could effectively interrupt the oxidative chain newlinereactions typically induced by acrylamide exposure. The study hypothesized that the newlinehydroxyl (OH) moiety at the C3 position newline