Development and Evaluation of Bio Sensing Strategy for NDV Antibody Detection

Abstract

The outbreak of infectious diseases and its economic impact on the poultry industry has evoked the need for advanced technologies for disease prevention and control. The increasing rate of morbidity and mortality during an outbreak necessitates the need for cost effective, rapid, on site technologies without the need of skilled personals. Vaccination plays a major role in disease control. Despite of the availability of several vaccines, eradication of a disease still remains a challenge due to the inability of the conventional vaccines to differentiate the infected from vaccinated animals (DIVA).This led to the need for the development of marker vaccines which in conjunction with diagnostic tools that are able to differentiate the infected animals from the vaccinated animals. The limitations possessed by conventional diagnostic tools has paved the way to the implementation of biosensors for its rapid, cost effective, on site detecting features. Extensive research has been carried out in the field of biosensors for antigen detection. But when it comes to biosensors for DIVA applications and antibody detection, limited works have been reported which is further exemplified by the challenges in antibody detection newline