Process development for the production of recombinant human interferon gamma hifn 915 in pichia pastoris cell factory

Abstract

Human interferon gamma hIFN 206 179 is a pleiotropic cytokine that is produced by natural killer cells and T lymphocytes hIFN 206 179 plays an key role in communicating innate and acquired immune systems during bacterial and viral infections it also possess antiviral immunoregulatory and anti tumor properties In the present study cell level and process level strategies were applied to address the expression machinery related and process related problems which are bottle neck for protein expressio