Formulation and Evaluation of Antimicrobial and Antileucorrheal Tablets of Herbal Origin

Abstract

In the present research work an attempt has been made to formulate and evaluate antileucorrheal tablets of herbal origin. A thorough literature survey was carried out to explore all kinds of therapy available for this disorder. Some herbal formulations are available but they have not been standardised by official evaluation methods. Keeping in view all these factors, an attempt was made to formulate a new polyherbal dosage form for the remedy and to carry out the pharmacological and other evaluation methods. Herbal products may contain a single herb or combination of several herbs believed to have complementary and/ or synergistic effects. The different ingredients may balance each other, buffer each other and act synergistically to make the systemic effect more powerful. In accordance with this fact, the present study was targeted towards the development of a polyherbal formulation. The polyherbal formulation was made from the combined extracts of various plants viz., Aloe vera, Asteracantha longifolia, Erythrina indica, Hemidesmus indicus, Saraca indica, Symplocos racemosa and Tribulus terrestris. The selection of the plants for the study was made on the basis of the literature survey conducted. The literature survey revealed the potential of these plants in the treatment of leucorrhea. The formulation was subjected to elemental analysis by X-ray fluorescence spectroscopy. The results of XRF studies are indicative of the safety standards of the formulation. The identity of the formulation was assessed on the basis of the HPTLC finger print profile. HPTLC and GC-MS analysis were conducted for the characterisation of extract and formulation. The HPTLC and GC-MS chromatograms showed good correlation between extract and formulation. The present work has shown promising results in the treatment of Leucorrhea. The studies may further be extended to the isolation of the active phytoconstituents in the formulation and evaluation of biological activities with the isolated compounds.