A comparative study of ethanolic extract of Sargassum wightii and the isolated molecule fucoidan in streptozotocin induced diabetic Wistar rats using biochemical histomorphological and histochemical parameters

Abstract

Despite numerous studies that have been made in understanding and newlinemanagement of diabetes, its related complications are increasing. Remedies newlinefrom terrestrial herbs and marine algae were used with success to treat newlinediabetes. Many traditional plants are used in the treatment of diabetes newlinethroughout the world and there is an increasing demand for natural products. newlineTraditional medicinal plants have hypoglycemic effects and potential newlineeffectiveness against diabetes; it is inferred that these plants have a major newlinerole to play in the management of diabetes. Many new bioactive molecules newlineisolated from traditional medicinal plants have hypoglycemic effects newlinecomparable to the known oral hypoglycemic agents. Among traditional plants, newlinemarine seaweeds received much attention due to their abundant source of newlinepolysaccharides. The sulfated polysaccharides of seaweeds have been newlinereported to possess diverse biological activities of pharmaceutical value. newlineNumerous studies have been made on the antioxidant, antimicrobial, antiinflammatory, newlineand immunomodulatory efficiency of crude extracts of newlineseaweeds. The importance of seaweed products in the pharmaceutical newlineindustry has become increasingly apparent considering their characteristics newlinesuch as anticoagulants, enzyme inhibitors, antiviral and antithrombotic newlineactivities. The pharmaceutical potential of the purified form of seaweed newlinepolysaccharides, in particular, the fucoidan as an antidiabetic agent needs to newlinebe explored. Viewing the above facts, the present study on the effect of Sargassum wightii ethanolic extract, and its isolated molecule; fucoidan on diabetes mellitus was undertaken. newline