Preparation And Characterization Of Solid Lipid Nanoparticles Of Few Active Pharmaceutical Ingredients Using Quality By Design Approach

Abstract

The majorities of active pharmaceutical drug substances lack specificity, are toxic/poisonous, unstable, or are inactivated or eliminated before they reach their intended target. To resolve these issues, molecular modeling has previously been used effectively with several medicines. The complexity of the drug molecules, the unpredictability of their behavior in the biological environment, and the high costs limit the configuration modifications of the molecules. However, it is obvious that structurally altering medications, enzymes, vaccines, and genes is unlikely to result in new molecules that will successfully reach and operate in the places where a pharmacological intervention is required, at least for the majority of these molecules. The only option available at this time is to maximize drug activity through the employment of systems that will protect the drug in the biological environment, transport the drug to the site of action, and release the drug under regulated conditions. In this regard, the use of new drug delivery systems has piqued the interest of numerous academic, pharmaceutical, and cosmetic researchers. High bioavailability of drug, tissue targeting, controlled release kinetics, minimum immunity response, easy drug administration for patient compliance, and the ability to deliver traditionally difficult drugs such as lipophiles, amphiphiles, and biomolecules are all commonly accepted criteria for advanced drug delivery systems1. newlineWretlind created the first fat emulsion (intralipid) for parenteral nutrition in the 1960s2. This marked the start of a novel method for the easy incorporation of lipophilic medications into oil droplets. However, the main benefit is the physical stability of the drug-containing emulsions because of a decrease in zeta potential, which can otherwise cause agglomeration, drug expulsion, and eventually breakdown of the emulsion3. Lipophiles, or substances that are poorly soluble in water, have crucial and advantageous functions in a variety of biological processes. Most