Olecular mechanism and herb drug Interaction of hydro alcoholic extract of Terminalia arjuna bark and its ayurvedic Formulations in metabolic syndrome

Abstract

ABSTRACT newlineDisorders like obesity, diabetes mellitus (DM), dyslipidemia and hypertension are newlinegrouped under metabolic syndrome (MS) with complex etiology, multifactorial newlinepathogenesis and require prophylactic and therapeutic interventions. In our traditional newlineknowledge and Indian civilizations, different herbal medicines have been advocated newlinefor DM. It is notable that Terminalia arjuna (TA) utilized in dyslipidemia, newlinehyperglycemia, malignancy, high blood pressure and hypercholesterolemia. newlineArjunarishta (AA) and Arjun Ghritah (AG) are hydroalcoholic and ghee based newlineformulation of TA respectively. These ayurvedic medicines were used to treat a lipid newlineand cardiovascular disorders. Herbs are taken with the belief that they are helpful and newlinesafe in reducing side and adverse effects of prescription drugs. This leads to increased newlineincidences of herb-drug interactions (HDIs). As adequate gaps present in the literature newlineabout the molecular mechanism, and HDIs, more research study in this direction is newlinerequired to cover the essential issues. newlineObjectives: newlineThe objective of the study was to assess the molecular mechanism and HDI of hydro newlinealcoholic TA extract (TAHA) of bark and its ayurvedic formulations in MS newline