PREPARATION CHARACTERIZATION AND ANTIDIABETIC EFFICACY OF NANOPARTICLES OF NATURAL BENZOQUINONE AND ITS METAL COMPLEXES AN APPROACH UNDER IN VITRO DOCKING AND IN VIVO ANIMAL MODEL STUDIES

Abstract

Diabetes mellitus DM has been known since many years ago and Sushruta has mentioned the sweetness of diabetic urine in Ayurveda DM is a chronic metabolic disorder with multiple etiologies shares the phenotype of hyperglycemia with disturbances of carbohydrate fat and protein metabolism Solomon et al 2012 Recently the prevalence of diabetes has increased enormously across the globe and in the present scenario its a worldwide public health problem It is considered to be one of the major leading causes of death of human Chauhan et al 2010 Globally there is a shift from communicable to chronic noncommunicable diseases over the past few decades Lim et al 2013 and Lozano et al 2013 Furthermore the total number of people with diabetes is projected to rise from 171 million in 2000 to 366 million in 2030 if successful strategies are not implemented for prevention and control Pandey et al 2012 and Tripathi et al 2013 According to the International Diabetes Federation 80 percentage of patient lives in low and middle income countries Unwin et al 2011 and about 50 percentage of diabetes patient remain undiagnosed Harris et al 2000 and Mohan et al 2005Indian scenario suggested that about 624 million people are diabetes in the year 2011 according to the report of Indian Council of Medical Research India Diabetes Study ICMR INDIAB study Anjana et al 2011 and it will be increased to 1012 million by 2030 Unwin et al 2011 newline newline newline newline