Development and characterization of nanosuspension based drug delivery systems

Abstract

Certain drugs exhibit poor solubility; such drugs will be eliminated from the body permanently once their blood plasma concentration has been reached (plasma half-life). Low solubility turns into the rate-limiting step in the absorption process; as a result, no enough drug enters the systemic circulation to generate the appropriate plasma concentration and, consequently, therapeutic action. Thus, to achieve the expected therapeutic impact, it is imperative to investigate straightforward, time- and money-saving technique for boosting the solubility of poorly soluble API. newlineThus, the present investigation is aimed at solubility enhancement through nanotechnology by formation of nanosuspension. HPMC-K4M for tadalafil and Poloxamer-188 along with HPMC-E15 for voriconazole as a stabilizer in nanoparticles was successfully assessed to address the solubility concern of BCS class II drugs. Nanoparticles exhibited particle size, polydispersity index and zeta potential with in specified limits. Morphological examinations of nanoparticles suggested that particles were small enough, typically in the nanometer range, to lessen mechanical irritation of the mucosal membrane. Drug excipients compatibility studies indicated compatibility between drug and adjuvants employed. Oral thin films of tadalafil exhibited better appearance, pH in range of 6.69 to 6.84, thickness from 0.185 mm to newline0.308 mm. Drug content was in range of 89.41±1.09 and 94.84±0.96. Film exhibited effective mechanical strength as demonstrated by folding endurance. Disintegration time for optimized batch was 95.96±0.78 with cumulative drug release to be 90.13±1.21- 97.11±0.63 % within 10 minutes. Thus, it could be interpreted that developed oral thin films exhibited superior qualities in context of oral drug delivery. newlineOptimized formulation of voriconazole in situ gel was developed using a 32-factorial design. This optimized formulation demonstrated a release profile that satisfied the criteria for ideal topical formulation. Poloxamer-188 imparted surfactant feature