Evaluation of Hematological and Biochemical Parameters in patients of sickle cell diseases

Abstract

Sickle cell disease (SCD) is an inherited hemolytic blood newlinedisorder. The prevalence of SCD is high among the people whose newlineforefathers originated from sub-Saharan Africa, India, Saudi-Arabia and newlineMediterranean countries. In India, SCD is second most common newlinehaemoglobin disorder, next to thalassemia. SCD is highly prevalent in the newlinecentral India, southern and north-eastern states of the country [1-9]. newline SCD is an autosomal recessive, genetic disorder caused due to a newlinepoint mutation at the and#946;-globin gene on the short arm of chromosome 11 of newlineadult hemoglobin (HbA). Substitution of thymine for adenine (GAG GTG) newlinereplaces glutamic acid (a water soluble amino acid) with valine (a fat newlinesoluble amino acid) at the sixth position of the and#946; -globin chain [10,11]. newline