Respiratory motion prediction of lung tumor using artificial intelligence

Abstract

Managing respiratory motion in radiotherapy for lung cancer presents a formidable and newlinepersistent challenge. The inherent dynamic movement triggered by respiration introduces a notable degree of uncertainty in target delineation, impacting the precision of image-guided radiotherapy. Overlooking the impact of respiratory motion can lead to the emergence of artifacts in images during image acquisition, resulting in inaccuracies in tissue delineation. Moreover, the motion between treatment fractions can induce blurriness in the dose distribution within the treatment process, thereby introducing geometric and dosimetric uncertainties. Additionally, inter-fraction motion can result in the displacement of the distribution of administered doses. Given these complexities, the precise prediction of tumor motion holds the utmost importance in newlineelevating the quality of treatment administration and minimizing radiation exposure to healthy tissues neighboring the pertinent organ during radiotherapy. Nonetheless, achieving the desired level of precision in dose administration remains a formidable task due to the inherent variations in internal patient anatomy across varying time scales and magnitudes. While notable advancements have been witnessed in radiotherapy, attributed to innovations like image guidance tools, which have streamlined treatments, the challenge of accommodating lung tumor motion remains critical, particularly in cases related to newlineradiotherapeutic intervention. Substantial limitations endure despite integrating respiratory-gated techniques in radiation oncology to manage lung tumor motion. Moreover, lung cancer prognosis remains low, irrespective of the recent advancements in radiotherapy. The practice of expanding newlinetreatment margins from the Clinical Treatment Volume (CTV) to encompass the Planning newlineTreatment Volume (PTV) has been adopted as a strategy to amplify treatment outcomes. newlineHowever, this strategy necessitates a trade-off, as it inevitably exposes larger volumes of healthy tissues to radiation.