Method Development for Impurities in some Multicomponent Dosage Forms and Cardiovascular Drugs

Simple item page
dc.contributor.guideThomas, K Men_US
dc.contributor.guideMukkanti, K
dc.coverage.spatialChemistryen_US
dc.creator.researcherAparna, Ponnalaen_US
dc.date.accessioned2014-05-30T11:11:38Z
dc.date.available2014-05-30T11:11:38Z
dc.date.awardedn.den_US
dc.date.completed2013en_US
dc.date.issued2014-05-30
dc.date.registeredn.den_US
dc.description.abstractChapter-1 is about general introduction of impurities and method development. newlineChapter-2 describes about an unknown impurity formed in 50°C stability samples at 3 months in Lamivudine, Zidovudine and Nevirapine tablets for oral suspension which was detected by the new HPLC method. This degradation product was isolated by using newlinepreparative chromatography. The chemical structure of the degradant was elucidated by MS, 1H-NMR, 13C-NMR, DEPT and IR. The data newlineindicated that the structure as 1-[5-Hydroxymethyl-4-(5-methyl-2,3- dihydro-[1,2,3]triazole-1yl)-tetrahydro-furan-2-yl]-5-methyl-1Hpyrimidine- 2,4-(1H,3H)-dione. The mechanism of formation of this newlineimpurity is described in detailen_US
dc.description.noteNoneen_US
dc.format.accompanyingmaterialNoneen_US
dc.format.dimensions-en_US
dc.format.extent141 p.en_US
dc.identifier.urihttp://hdl.handle.net/10603/18837
dc.languageEnglishen_US
dc.publisher.institutionFaculty of Chemistryen_US
dc.publisher.placeKukatpallyen_US
dc.publisher.universityJawaharlal Nehru Technological University, Hyderabaden_US
dc.relation-en_US
dc.rightsuniversityen_US
dc.source.inflibnetINFLIBNETen_US
dc.subject.keywordCardiovascularen_US
dc.subject.keywordDosageen_US
dc.subject.keywordDrugsen_US
dc.subject.keywordImpuritiesen_US
dc.subject.keywordMulticomponenten_US
dc.titleMethod Development for Impurities in some Multicomponent Dosage Forms and Cardiovascular Drugsen_US
dc.title.alternative-en_US
dc.type.degreePh.D.en_US

Files

Original bundle

Now showing 1 - 5 of 8
Thumbnail Image
Name:
01_title.pdf
Size:
6.7 KB
Format:
Adobe Portable Document Format
Description:
Attached File
Download
Thumbnail Image
Name:
02_abstract.pdf
Size:
77.67 KB
Format:
Adobe Portable Document Format
Download
Thumbnail Image
Name:
03_chapter 1.pdf
Size:
597.34 KB
Format:
Adobe Portable Document Format
Download
Thumbnail Image
Name:
04_chapter 2.pdf
Size:
517.18 KB
Format:
Adobe Portable Document Format
Download
Thumbnail Image
Name:
05_chapter 3.pdf
Size:
273.11 KB
Format:
Adobe Portable Document Format
Download

License bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download

Collections

Department of Chemistry